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Project Number: | I01CX001490-01A1 |
| Title: | Metabolomics study in patients post myocardial infarction |
| Principal Investigator: | Nipavan Chiamvimonvat |
| Location: | Martinez, CA |
| Congressional District Code: | 7 |
| Research Service: | Clinical Science R&D |
| Project Period: | April 2017 - March 2022 |
| FY 2021 Funding Amount: | $82,500 |
| Total Award Amount (all years): |
$720,150 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: ABSTRACT This proposal represents a bench-to-bedside study to translate our recent findings in small animal models into the clinic. Cardiac remodeling is the heart’s prevailing response to extrinsic and intrinsic stimuli including pressure or volume overload, mutations of sarcomeric proteins, or loss of contractile mass from myocardial infarction (MI). Adverse cardiac remodeling is driven at the cellular level by myocyte hypertrophy, apoptosis, microvascular dysfunction, fibrosis, and electrica... |