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Funded Project Details - FY2021




Project Number:

I01CX001441-01A1
Title: Role of SIRT3 in melanoma development and progression
Principal Investigator:

Nihal Ahmad

Location: Madison, WI
Congressional District Code: 2
Research Service: Clinical Science R&D
Project Period: April 2017 - December 2021
FY 2021 Funding Amount: $82,500
Total Award Amount
(all years):
$747,500
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

Melanoma, one of the deadliest cancer of skin, arises from melanocytic cells that are responsible for melanin production. Recent advances in the understanding of melanoma biology has led to the development of targeted therapies with promise. For example, BRAF inhibitors vemurafenib and dabrafenib achieved significant improvement over chemotherapy and were approved for metastatic melanomas with BRAF- mutations. More recently, the combination of dabrafenib with MEK inhibitor trametinib demonstrate...



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