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Funded Project Details - FY2021

Project Number:

Title: Role of IL-6 and IL-1b in immune dysfunction during aging, HIV, and HCV infection
Principal Investigator:

Carey Shive

Location: Cleveland, OH
Congressional District Code: 11
Research Service: Clinical Science R&D
Project Period: January 2017 - December 2021
FY 2021 Funding Amount: $202,612
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Chronic systemic inflammation is associated with immune dysfunction and morbidities in the elderly, treated HIV infection, and HCV infection. We propose that circulating inflammatory proteins drive immune exhaustion and senescence and contribute to the immune dysfunction seen in these patient groups. Nearly 4 million Americans are infected with Hepatitis C Virus (HCV) and the mean age of US veterans infected with HCV is nearing 65 years. Although the new IFN-free direct-acting antiviral therapy...

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