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Funded Project Details - FY2021




Project Number:

I01BX003644-01
Title: Upstream regulation of TAZ and YAP in sarcomas: towards combinatorial therapy targeting the Hippo Pathway
Principal Investigator:

Munir R Tanas

Location: Iowa City, IA
Congressional District Code: 2
Research Service: Biomedical Laboratory R&D
Project Period: January 2017 - December 2020
FY 2021 Funding Amount: $71,250
Total Award Amount
(all years):
$695,322
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

Sarcomas are cancers arising within bone and soft tissue which rank among the most difficult cancers to treat. Limb-salvage therapy has reduced the incidence of disfiguring amputations, however many sarcomas involve crucial anatomical structures precluding this approach. Additionally, five year survival for metastatic sarcomas is only 16%, underscoring the need for new therapeutic targets. The Hippo pathway is a highly conserved serine/threonine kinase cascade which negatively regulates the TAZ...



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