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Funded Project Details - FY2021

Project Number:

Title: Purinergic Mechanisms in Homeostatic Sleep Control
Principal Investigator:

Radhika Basheer

Location: Brockton, MA
Congressional District Code: 7
Research Service: Biomedical Laboratory R&D
Project Period: January 2017 - December 2021
FY 2021 Funding Amount: $220,414
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


The broad objective of this proposal is to understand the cellular mechanisms which control sleepiness. Sleep deprivation (SD) and insomnia are experienced by ~40% of military personnel immediately after deployment and SD is a well-known risk factor that adversely affects the mental health of veterans. The basal forebrain (BF) is an important brain region for controlling the increased propensity for sleep after SD i.e. sleep homeostasis. Previous grant cycles investigated how sleep homeostasis i...

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