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Funded Project Details - FY2021

Project Number:

Title: Inhibitory G protein (Gi) signaling in bone disease and repair
Principal Investigator:

Robert A. Nissenson

Location: San Francisco, CA
Congressional District Code: 12
Research Service: Biomedical Laboratory R&D
Project Period: October 2016 - March 2021
FY 2021 Funding Amount: $247,785
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


The differentiation of mesenchymal progenitor cells (MPCs) in the bone marrow environment is a crucial determinant of bone mass, whole body metabolism, and bone repair. However, the mechanisms that regulate MPC differentiation are poorly understood. This proposal is based on the hypothesis that MPCs serve to sense metabolic stress which then directs their differentiation. In this view, the control of adipogenic vs. osteogenic differentiation of MPCs is a mechanism for balancing structural/biomec...

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