Funded Project Details - FY2021
|Title:|| Inhibitory G protein (Gi) signaling in bone disease and repair|
Robert A. Nissenson
||San Francisco, CA
|Congressional District Code:
||Biomedical Laboratory R&D
|| October 2016 -
|FY 2021 Funding Amount:
|Total Award Amount
View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER
The differentiation of mesenchymal progenitor cells (MPCs) in the bone marrow environment is a crucial determinant of bone mass, whole body metabolism, and bone repair. However, the mechanisms that regulate MPC differentiation are poorly understood. This proposal is based on the hypothesis that MPCs serve to sense metabolic stress which then directs their differentiation. In this view, the control of adipogenic vs. osteogenic differentiation of MPCs is a mechanism for balancing structural/biomec...
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