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Funded Project Details - FY2021

Project Number:

Title: How Does Nicotine Impair Macrophage Killing of Mycobacterium Tuberculosis? 
Principal Investigator:

Edward D. Chan

Location: Denver, CO
Congressional District Code: 1
Research Service: Clinical Science R&D
Project Period: October 2017 - September 2021
FY 2021 Funding Amount: $165,000
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Nicotine at physiologic concentrations impairs macrophage killing of Mycobacterium tuberculosis (MTB), resulting in a 2-5 fold increase in bacterial burden. We have also found that preventing nicotine binding – either pharmacologically or by genetic disruption of the nicotinic receptor – significantly mitigated cigarette smoke extract-induced impairment of macrophage killing of MTB. But the mechanisms by which nicotine impairs macrophage control of MTB are not known. Our hypothesis is that nicot...

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