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Project Number: | I01CX001452-01A1 |
| Title: | How Does Nicotine Impair Macrophage Killing of Mycobacterium Tuberculosis? |
| Principal Investigator: | Edward D. Chan |
| Location: | Denver, CO |
| Congressional District Code: | 1 |
| Research Service: | Clinical Science R&D |
| Project Period: | October 2017 - September 2021 |
| FY 2021 Funding Amount: | $165,000 |
| Total Award Amount (all years): |
$747,409 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: Nicotine at physiologic concentrations impairs macrophage killing of Mycobacterium tuberculosis (MTB), resulting in a 2-5 fold increase in bacterial burden. We have also found that preventing nicotine binding – either pharmacologically or by genetic disruption of the nicotinic receptor – significantly mitigated cigarette smoke extract-induced impairment of macrophage killing of MTB. But the mechanisms by which nicotine impairs macrophage control of MTB are not known. Our hypothesis is that nicot... |