Funded Project Details - FY2021
|Title:|| How Does Nicotine Impair Macrophage Killing of Mycobacterium Tuberculosis? |
Edward D. Chan
|Congressional District Code:
||Clinical Science R&D
|| October 2017 -
|FY 2021 Funding Amount:
|Total Award Amount
View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER
Nicotine at physiologic concentrations impairs macrophage killing of Mycobacterium tuberculosis (MTB), resulting in a 2-5 fold increase in bacterial burden. We have also found that preventing nicotine binding – either pharmacologically or by genetic disruption of the nicotinic receptor – significantly mitigated cigarette smoke extract-induced impairment of macrophage killing of MTB. But the mechanisms by which nicotine impairs macrophage control of MTB are not known. Our hypothesis is that nicot...
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