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Funded Project Details - FY2021

Project Number:

Title: The Vitamin D-Gelsolin-S1P Axis in Rheumatoid Arthritis
Principal Investigator:

Arnold E. Postlethwaite

Location: Memphis, TN
Congressional District Code: 9
Research Service: Clinical Science R&D
Project Period: October 2016 - March 2021
FY 2021 Funding Amount: $0
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Vitamin D deficiency (VitD-) is commonly encountered in patients with rheumatoid arthritis (RA) (and other autoimmune diseases). Some studies show VitD levels impact expression of RA, but the mechanism(s) have not been well explored and have received scant attention in rodent models of RA. Interestingly, like VitD levels, in studies looking at only plasma gelsolin (pGSN), it was observed that pGSN levels also inversely correlate with C-reactive protein (CRP) in patients with RA. Gelsolin (GSN) h...

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