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Funded Project Details - FY2021

Project Number:

Title: Modulating microglial phenotype to prevent SCI-induced central neuropathic pain
Principal Investigator:

Mousumi Ghosh

Location: Miami, FL
Congressional District Code: 18
Research Service: Rehabilitation R&D
Project Period: June 2017 - December 2022
FY 2021 Funding Amount: $181,732
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


A significant percentage (40-50%) of individuals with spinal cord injury (SCI) exhibit central neuropathic pain (CNP), a condition of persistent discomfort involving often unbearable burning, pricking, shooting and/or evoked types of pain in response to light touch. CNP appears more frequently in females, who also exhibit a greater sensitivity to pain than males. CNP develops in response to a dysregulation of somatosensory signaling and is largely refractory to conventional therapeutic intervent...

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