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Funded Project Details - FY2021




Project Number:

I01RX002323-01A1
Title: Vascular Endothelial Function: A Potential Therapeutic Target in Alzheimer's Disease
Principal Investigator:

Russell S. Richardson

Location: Salt Lake City, UT
Congressional District Code: 2
Research Service: Rehabilitation R&D
Project Period: September 2017 - August 2023
FY 2021 Funding Amount: $0
Total Award Amount
(all years):
$1,100,000
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

The medical, social, and economic burdens that Alzheimer's disease (AD) and the prodromal stage of this pathology, mild cognitive impairment (MCI), place on Veterans has stimulated efforts to identify therapeutic targets to modify their progression. Recent evidence suggests that, in addition to vascular abnormalities in AD, a deficiency in endothelium-derived nitric oxide (NO) may contribute to the production and accumulation of AD- related neurotoxins such as amyloid beta (Aβ). As challenges, w...



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