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Funded Project Details - FY2021




Project Number:

I01RX002259-01A1
Title: A Dominantly Inherited AD network In Vitro Trial with a Gamma-Secretase Modulator
Principal Investigator:

Steven Wagner

Location: San Diego, CA
Congressional District Code: 52
Research Service: Rehabilitation R&D
Project Period: June 2017 - May 2021
FY 2021 Funding Amount: $146,241
Total Award Amount
(all years):
$977,511
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

Alzheimer’s disease (AD) is defined neuropathologically by extracellular plaques composed of β-amyloid (Aβ42) and intracellular tangles consisting of hyperphosphorylated forms of the microtubule-associated protein tau. Aβ accumulation and hyperphosphorylation of tau are recognized as key events leading to full blown AD neuropathology. Here we propose comprehensive in vitro analysis of a unique set of novel small molecule drugs known gamma- secretase modulators (GSMs) to further explore AD therap...



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