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Project Number: | I01RX002259-01A1 |
| Title: | A Dominantly Inherited AD network In Vitro Trial with a Gamma-Secretase Modulator |
| Principal Investigator: | Steven Wagner |
| Location: | San Diego, CA |
| Congressional District Code: | 52 |
| Research Service: | Rehabilitation R&D |
| Project Period: | June 2017 - May 2021 |
| FY 2021 Funding Amount: | $146,241 |
| Total Award Amount (all years): |
$977,511 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: Alzheimer’s disease (AD) is defined neuropathologically by extracellular plaques composed of β-amyloid (Aβ42) and intracellular tangles consisting of hyperphosphorylated forms of the microtubule-associated protein tau. Aβ accumulation and hyperphosphorylation of tau are recognized as key events leading to full blown AD neuropathology. Here we propose comprehensive in vitro analysis of a unique set of novel small molecule drugs known gamma- secretase modulators (GSMs) to further explore AD therap... |