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Funded Project Details - FY2021




Project Number:

I01RX002335-01A1
Title: Testosterone and APOE genotype interactions following mild traumatic brain injury
Principal Investigator:

Rebecca C Klein

Location: Durham, NC
Congressional District Code: 1
Research Service: Rehabilitation R&D
Project Period: January 2017 - December 2021
FY 2021 Funding Amount: $68,750
Total Award Amount
(all years):
$1,100,000
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

Nearly 20% of US troops deployed in Iraq and Afghanistan conflicts are estimated to have suffered probable traumatic brain injury (TBI). Among survivors, the loss of circulating levels of testosterone (hypogonadism) is one of the most frequently reported deficits, and the long-term effects may dramatically increase the risk of multiple symptoms including PTSD, depression, anxiety, and cognitive loss. The 4 allele of apolipoprotein E is the strongest risk factor for developing Alzheimer’s diseas...



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