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Funded Project Details - FY2021

Project Number:

Title: Immunotherapeutic Regulatory CD8 T cells in Autoimmune Demyelinating Disease
Principal Investigator:

Nitin Karandikar

Location: Iowa City, IA
Congressional District Code: 2
Research Service: Biomedical Laboratory R&D
Project Period: July 2017 - June 2021
FY 2021 Funding Amount: $123,750
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Multiple sclerosis (MS) is an inflammatory, demyelinating disorder of the central nervous system (CNS). A great deal of our understanding about the immunologic processes that underlie MS derives from studies in its autoimmune animal model, experimental autoimmune encephalomyelitis (EAE). However, the vast majority of studies in EAE and MS have focused on evaluating and targeting CD4+ T cell responses, with the general assumption that these diseases are predominantly Th1/Th17-mediated and Th2/Tre...

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