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Funded Project Details - FY2021

Project Number:

Title: NKLAM: An RBR E3 Ubiquitin Ligase Essential for Regulation of Innate Immunity
Principal Investigator:

Jacki Kornbluth

Location: St Louis, MO
Congressional District Code: 1
Research Service: Biomedical Laboratory R&D
Project Period: April 2017 - September 2021
FY 2021 Funding Amount: $157,500
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


The innate immune system serves is the first response to diseased cells and infectious agents. Natural Killer (NK) cells and macrophages are primary components of this system. Although their functions differ, they both require the expression of NKLAM (Natural Killer Lytic-Associated Molecule) for optimal function. Accordingly, elucidating the role of NKLAM in innate immunity has important biological and clinical significance. NKLAM is up-regulated in NK cells upon exposure to tumor cells or cyt...

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