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Funded Project Details - FY2021

Project Number:

Title: Mitochondrial CAMKII in smooth muscle as key regulator of hypertension and vascular remodeling
Principal Investigator:

Isabella Grumbach

Location: Iowa City, IA
Congressional District Code: 2
Research Service: Biomedical Laboratory R&D
Project Period: July 2017 - June 2021
FY 2021 Funding Amount: $123,750
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Despite multiple initiatives in the VA healthcare system, at least 30% of the estimated three million Veterans with hypertension do not reach the current target blood pressure (BP). Hypertension induces pathological remodeling of the vascular wall, leading to further increases in BP and end organ dysfunction. These effects are linked to 5,000 annual deaths among Veterans. Emerging data suggest that mitochondrial ROS production is a common denominator in hypertension, but mechanistic concepts of...

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