Funded Project Details - FY2021
|Title:|| Determine if a candidate dengue vaccine in advanced trials induces antigen-specific cellular immunity that mimics immunity after multiple infections and controls antibody-enhanced viral replication|
Sarah L. George
||St Louis, MO
|Congressional District Code:
||Biomedical Laboratory R&D
|| July 2017 -
|FY 2021 Funding Amount:
|Total Award Amount
View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER
Dengue (DV) disease is a major and spreading global health problem. Transmission is now endemic in at least one U.S. state; hundreds of veterans were affected by a DV outbreak in 2007-10. Most severe DV disease is mediated by antibody-mediated enhancement of infection (ADE) inwhich antibodies from a prior infection with another DV serotype or maternal-infant transmission facilitate viral entry and replication. A 7.5- fold increased risk of severe DV disease is seen in DV-naïve recipients of the...
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