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Funded Project Details - FY2021




Project Number:

I01BX003714-01A1
Title: Determine if a candidate dengue vaccine in advanced trials induces antigen-specific cellular immunity that mimics immunity after multiple infections and controls antibody-enhanced viral replication
Principal Investigator:

Sarah L. George

Location: St Louis, MO
Congressional District Code: 1
Research Service: Biomedical Laboratory R&D
Project Period: July 2017 - June 2023
FY 2021 Funding Amount: $0
Total Award Amount
(all years):
$639,462
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

Dengue (DV) disease is a major and spreading global health problem. Transmission is now endemic in at least one U.S. state; hundreds of veterans were affected by a DV outbreak in 2007-10. Most severe DV disease is mediated by antibody-mediated enhancement of infection (ADE) inwhich antibodies from a prior infection with another DV serotype or maternal-infant transmission facilitate viral entry and replication. A 7.5- fold increased risk of severe DV disease is seen in DV-naïve recipients of the...



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