Talk to the Veterans Crisis Line now
U.S. flag
An official website of the United States government
ORD only    All VA Research websites

Office of Research & Development

print icon sign up for VA Research updates

Funded Project Details - FY2021

Project Number:

Title: Determine if a candidate dengue vaccine in advanced trials induces antigen-specific cellular immunity that mimics immunity after multiple infections and controls antibody-enhanced viral replication
Principal Investigator:

Sarah L. George

Location: St Louis, MO
Congressional District Code: 1
Research Service: Biomedical Laboratory R&D
Project Period: July 2017 - June 2023
FY 2021 Funding Amount: $0
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Dengue (DV) disease is a major and spreading global health problem. Transmission is now endemic in at least one U.S. state; hundreds of veterans were affected by a DV outbreak in 2007-10. Most severe DV disease is mediated by antibody-mediated enhancement of infection (ADE) inwhich antibodies from a prior infection with another DV serotype or maternal-infant transmission facilitate viral entry and replication. A 7.5- fold increased risk of severe DV disease is seen in DV-naïve recipients of the...

Questions about the R&D website? Email the Web Team.

Any health information on this website is strictly for informational purposes and is not intended as medical advice. It should not be used to diagnose or treat any condition.