Funded Project Details - FY2021
|Title:|| Endothelial Cell Mineralocorticoid Receptor and Tubulointerstitial Fibrosis|
Adam T Whaley-Connell
|Congressional District Code:
||Biomedical Laboratory R&D
|| April 2017 -
|FY 2021 Funding Amount:
|Total Award Amount
View full abstract and other project information on NIH RePORTER
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Project Summary/Abstract Consumption of a western diet (WD) is a major contributor to the epidemic of obesity and associated insulin resistance, hypertension and kidney disease that afflict our Veteran population. Chronic kidney disease is increasing despite widespread use of renin-angiotensin-aldosterone system (RAAS) inhibition and aggressive blood pressure control. Higher circulating aldosterone levels and excess mineralocorticoid receptor (MR) activation, prevalent in obese, insulin resistan...
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