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Funded Project Details - FY2021

Project Number:

Title: Endothelial Cell Mineralocorticoid Receptor and Tubulointerstitial Fibrosis
Principal Investigator:

Adam T Whaley-Connell

Location: Columbia, MO
Congressional District Code: 4
Research Service: Biomedical Laboratory R&D
Project Period: April 2017 - March 2021
FY 2021 Funding Amount: $82,500
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Project Summary/Abstract Consumption of a western diet (WD) is a major contributor to the epidemic of obesity and associated insulin resistance, hypertension and kidney disease that afflict our Veteran population. Chronic kidney disease is increasing despite widespread use of renin-angiotensin-aldosterone system (RAAS) inhibition and aggressive blood pressure control. Higher circulating aldosterone levels and excess mineralocorticoid receptor (MR) activation, prevalent in obese, insulin resistan...

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