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Funded Project Details - FY2021

Project Number:

Title: Transformation of NOTCH3 protein in cerebral small vessel disease
Principal Investigator:

Michael M Wang

Location: Ann Arbor, MI
Congressional District Code: 12
Research Service: Biomedical Laboratory R&D
Project Period: October 2017 - September 2021
FY 2021 Funding Amount: $165,000
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


ABSTRACT Cerebral small vessel disease (SVD) affects over half of Americans over 65 and is a major risk factor for stroke and dementia. Although the pathological changes in blood vessels in SVD have been described for decades, the precise molecular defects are unclear. CADASIL is the most common inherited form of SVD and is caused by mutations in NOTCH3. We investigate the pathogenesis of CADASIL as a potential window into uncovering targetable mechanisms of vascular degeneration of the brain. M...

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