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Funded Project Details - FY2021




Project Number:

I01BX003382-01A1
Title: A Novel Relationship Between the Gut Microbiota and Pancreatic Beta Cells contributes to Gestational Glucose Homeostasis
Principal Investigator:

Brian Layden

Location: Chicago, IL
Congressional District Code: 7
Research Service: Biomedical Laboratory R&D
Project Period: April 2017 - March 2021
FY 2021 Funding Amount: $82,500
Total Award Amount
(all years):
$751,050
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

The human gut microbiota undergoes compositional changes during pregnancy, and these bacterial changes have been shown to influence maternal metabolic responses; however, how this occurs is unclear. Part of these maternal metabolic changes include enhanced glucose stimulated insulin secretion (GSIS) and an expansion of pancreatic β cell mass (BCM). Providing a potential understanding of how the gut microbiota mediates this maternal response, we have new data suggesting a relationship may exist d...



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