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Funded Project Details - FY2021




Project Number:

I01BX003443-01A2
Title: Regulation of intestinal NaCl absorption
Principal Investigator:

Uma Sundaram

Location: Huntington, WV
Congressional District Code: 3
Research Service: Biomedical Laboratory R&D
Project Period: July 2017 - June 2022
FY 2021 Funding Amount: $117,600
Total Award Amount
(all years):
$691,250
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

Diarrheal diseases afflict U.S. Veterans both at home and abroad. While the causes may be more acute overseas and more chronic in U.S., diarrhea in these conditions is a result of altered electrolyte (e.g. Na, Cl) and fluid transport in the intestine. For example, alterations in epithelial electrolyte transporters (e.g. Na:H and Cl:HCO3 exchange) is caused by immune inflammatory mediators known to be elevated in the mucosa of the chronically inflamed intestine (e.g. Inflammatory bowel disease, I...



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