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Project Number: | I01BX001245-05A2 |
| Title: | Luminal Factors Affecting Duodenal Protection and Chemosensing |
| Principal Investigator: | Jonathan D. Kaunitz |
| Location: | West Los Angeles, CA |
| Congressional District Code: | 33 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | July 2017 - December 2021 |
| FY 2021 Funding Amount: | $117,958 |
| Total Award Amount (all years): |
$778,212 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: Broad objectives: We plan to test the novel hypothesis that the potent bacterial toxin lipopolysaccharide (LPS) enters the circulation either through paracellular uptake into the portal vein, or by a transepithelial mechanism similar to that of long-chain fat absorption, with entry into the lymph. We have shown data that the intestinotrophic and protective hormone glucagon-like peptide (GLP)-2 is released from enteroendocrine cells in response to the systemic administration of LPS, presumably by... |