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Funded Project Details - FY2021

Project Number:

Title: Luminal Factors Affecting Duodenal Protection and Chemosensing
Principal Investigator:

Jonathan D. Kaunitz

Location: West Los Angeles, CA
Congressional District Code: 33
Research Service: Biomedical Laboratory R&D
Project Period: July 2017 - December 2021
FY 2021 Funding Amount: $117,958
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Broad objectives: We plan to test the novel hypothesis that the potent bacterial toxin lipopolysaccharide (LPS) enters the circulation either through paracellular uptake into the portal vein, or by a transepithelial mechanism similar to that of long-chain fat absorption, with entry into the lymph. We have shown data that the intestinotrophic and protective hormone glucagon-like peptide (GLP)-2 is released from enteroendocrine cells in response to the systemic administration of LPS, presumably by...

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