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Funded Project Details - FY2021

Project Number:

Title: Interaction of environment and genetics in predisposition to inflammatory arthritis
Principal Investigator:

Holly Rosenzweig

Location: Portland, OR
Congressional District Code: 3
Research Service: Biomedical Laboratory R&D
Project Period: January 2018 - December 2021
FY 2021 Funding Amount: $302,453
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Arthritis, a chronic immune-mediated disease involving painful destruction of the joints, presents a considerable medical challenge to our US Veteran population due to incomplete understanding of its pathogenesis. An emerging paradigm proposes that self-reactive (or autoreactive) T cells influenced by genetic-environmental interactions initiate and perpetuate disease. Understanding how these factors contribute to generation of autoreactive T cells and their subsequent expansion and ability to ca...

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