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Funded Project Details - FY2021

Project Number:

Title: Modifying the Internal Globus Pallidus (GPi) in Parkinson's Disease: Role of Glutamate in Restoration
Principal Investigator:

Charles K. Meshul

Location: Portland, OR
Congressional District Code: 3
Research Service: Biomedical Laboratory R&D
Project Period: April 2017 - September 2021
FY 2021 Funding Amount: $302,950
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Following the loss of nigrostriatal dopamine (DA), there is increased activity of glutamate neurons within the subthalamic nucleus. These excitatory neurons project to the internal globus pallidus [GPi, or entopeduncular nucleus (EPN) in the rodent], which utilizes the inhibitory neurotransmitter, GABA (gamma aminobutyric acid). In Parkinson's disease (PD), deep brain stimulation (DBS) of the GPi results in improvement in motor function and provides symptomatic relief. However in a rodent PD mod...

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