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Funded Project Details - FY2021

Project Number:

Title: A Novel Locus in the Regulation of Human Water Balance
Principal Investigator:

David M. Cohen

Location: Portland, OR
Congressional District Code: 3
Research Service: Biomedical Laboratory R&D
Project Period: October 2017 - September 2021
FY 2021 Funding Amount: $165,000
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Hyponatremia, a relative excess of total body water, is the most frequently encountered electrolyte abnormality. Although some instances are readily attributed to heart, liver, or kidney failure, many are unexplained. Water excess causes confusion, lethargy, seizures, and death. Even mild hyponatremia causes reversible deficits in coordination and cognition. The applicant's preliminary data show that the plasma sodium concentration is highly individual (i.e., relatively constant in any one indiv...

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