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Funded Project Details - FY2021

Project Number:

Title: Understanding the Function of Tamm-Horsfall Protein in Acute Kidney Injury
Principal Investigator:

Tarek Ashkar

Location: Indianapolis, IN
Congressional District Code: 7
Research Service: Biomedical Laboratory R&D
Project Period: April 2017 - June 2021
FY 2021 Funding Amount: $112,482
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Acute kidney injury (AKI) is a major determinant of mortality and morbidity in hospitalized veterans. Understanding the pathophysiology of AKI is essential for the development of therapy. This application proposes to study the role of Tamm-Horsfall protein (THP) in AKI. This protein is expressed exclusively in the kidney by cells of the thick ascending limbs (TAL) of Henle. In the last funding cycle, we uncovered a key role of THP in mediating a protective tubular cross-talk in AKI. We showed th...

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