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Funded Project Details - FY2021




Project Number:

I01BX003762-01A1
Title: Regulation of cutaneous immune function and anti-tumor immune responses by PPARgamma-mediated transrepressive signaling
Principal Investigator:

Raymond Konger

Location: Indianapolis, IN
Congressional District Code: 7
Research Service: Biomedical Laboratory R&D
Project Period: April 2017 - March 2021
FY 2021 Funding Amount: $82,500
Total Award Amount
(all years):
$698,841
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

Skin cancer is primarily caused by environmental ultraviolet (UV) exposure from sunlight. We have shown that loss of peroxisome proliferator activated receptor gamma (PPARγ) in the epidermis of mice (Pparg-/-epi mice) promotes UV-induced skin cancer formation. We have also shown that the PPARγ agonist rosiglitazone (Rosig) protects mice against skin cancer formation. The historical method for classifying PPARγ ligands is by their ability to activate genes associated with adipogenesis through a p...



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