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Funded Project Details - FY2021

Project Number:

Title: Elucidating the Mechanisms that link the Shared Epitope, Periodontal Disease and Arthritis
Principal Investigator:

David D. Brand

Location: Memphis, TN
Congressional District Code: 9
Research Service: Biomedical Laboratory R&D
Project Period: April 2017 - March 2021
FY 2021 Funding Amount: $243,778
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Periodontal disease (PD) and Rheumatoid Arthritis (RA) have many features in common. PD is a chronic inflammatory disease of the periodontium, the soft and hard tissues supporting the teeth, and is characterized by the destruction of the alveolar bone as a result of the chronic bacterial challenge and a compromised immune response. RA is a chronic inflammatory disease of the diarthrodial joints which results in reduced mobility. Both diseases exhibit a strong genetic component, the “shared epitope...

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