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Funded Project Details - FY2021




Project Number:

I01BX003709-01A1
Title: Role of Cerebrovascular cells in tau processing following traumatic brain injury
Principal Investigator:

Corbin Bachmeier

Location: Bay Pines, FL
Congressional District Code: 13
Research Service: Biomedical Laboratory R&D
Project Period: July 2018 - June 2022
FY 2021 Funding Amount: $272,716
Total Award Amount
(all years):
$1,102,567
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

One of the prominent pathological features of traumatic brain injury (TBI) is the accumulation of hyperphosphorylated and aggregated tau species in the brain. Tau is a cytoplasmic protein which is believed to be restricted to the intracellular compartment of neurons. However, several recent studies have investigated the existence and role for tau in the extracellular compartments of the brain, and have indicated that increased levels of monomeric tau in the extracellular environment play a major...



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