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Project Number: | I01BX003709-01A1 |
| Title: | Role of Cerebrovascular cells in tau processing following traumatic brain injury |
| Principal Investigator: | Corbin Bachmeier |
| Location: | Bay Pines, FL |
| Congressional District Code: | 13 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | July 2018 - June 2023 |
| FY 2023 Funding Amount: | $0 |
| Total Award Amount (all years): |
$989,547 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: One of the prominent pathological features of traumatic brain injury (TBI) is the accumulation of hyperphosphorylated and aggregated tau species in the brain. Tau is a cytoplasmic protein which is believed to be restricted to the intracellular compartment of neurons. However, several recent studies have investigated the existence and role for tau in the extracellular compartments of the brain, and have indicated that increased levels of monomeric tau in the extracellular environment play a major... |