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Project Number: | I01BX003824-01 |
| Title: | Pathological protein generation in cerebral small vessel disease |
| Principal Investigator: | Michael M Wang |
| Location: | Ann Arbor, MI |
| Congressional District Code: | 12 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | April 2017 - September 2021 |
| FY 2021 Funding Amount: | $82,500 |
| Total Award Amount (all years): |
$716,379 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: ABSTRACT Cerebral small vessel disease (SVD) is an important cause of dementia and contributes to neurodegenerative disorders such as Alzheimer's and Parkinson's diseases. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common inherited cause of SVD. Clinical features of CADASIL include dementia, recurrent stroke, and psychiatric disorders. Understanding the pathology of CADASIL may lead to strategies to treat SVD. CADASIL is cause... |