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Funded Project Details - FY2021

Project Number:

Title: MicroRNA Regulation of Phospholipid Homeostasis in Alzheimer's Disease Pathogenesis
Principal Investigator:

Dongming Cai

Location: Bronx, NY
Congressional District Code: 13
Research Service: Biomedical Laboratory R&D
Project Period: July 2017 - December 2021
FY 2021 Funding Amount: $147,600
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Background The ApoE4 genotype is the strongest genetic risk factor for developing AD. However, the mechanisms that underlie this link between ApoE4 genotype and SAD are not well understood. Objective/Hypothesis The objectives are to understand the molecular underpinnings of the association between ApoE4-specific changes in miRNA profile and ApoE4-induced brain phospholipid dysregulation which leads to ApoE4 increased susceptibility to develop SAD. Our recent findings demonstrate that ApoE protei...

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