Funded Project Details - FY2021
|Title:|| MicroRNA Regulation of Phospholipid Homeostasis in Alzheimer's Disease Pathogenesis|
|Congressional District Code:
||Biomedical Laboratory R&D
|| July 2017 -
|FY 2021 Funding Amount:
|Total Award Amount
View full abstract and other project information on NIH RePORTER
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Background The ApoE4 genotype is the strongest genetic risk factor for developing AD. However, the mechanisms that underlie this link between ApoE4 genotype and SAD are not well understood. Objective/Hypothesis The objectives are to understand the molecular underpinnings of the association between ApoE4-specific changes in miRNA profile and ApoE4-induced brain phospholipid dysregulation which leads to ApoE4 increased susceptibility to develop SAD. Our recent findings demonstrate that ApoE protei...
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