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Funded Project Details - FY2021




Project Number:

I01BX003380-01A2
Title: MicroRNA Regulation of Phospholipid Homeostasis in Alzheimer's Disease Pathogenesis
Principal Investigator:

Dongming Cai

Location: Bronx, NY
Congressional District Code: 13
Research Service: Biomedical Laboratory R&D
Project Period: July 2017 - December 2021
FY 2021 Funding Amount: $147,600
Total Award Amount
(all years):
$883,692
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

Background The ApoE4 genotype is the strongest genetic risk factor for developing AD. However, the mechanisms that underlie this link between ApoE4 genotype and SAD are not well understood. Objective/Hypothesis The objectives are to understand the molecular underpinnings of the association between ApoE4-specific changes in miRNA profile and ApoE4-induced brain phospholipid dysregulation which leads to ApoE4 increased susceptibility to develop SAD. Our recent findings demonstrate that ApoE protei...



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