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Funded Project Details - FY2021

Project Number:

Title: Inhibiting pathological TDP-43 phosphorylation as a therapeutic strategy for ALS
Principal Investigator:

Brian C. Kraemer

Location: Seattle, WA
Congressional District Code: 9
Research Service: Biomedical Laboratory R&D
Project Period: April 2017 - March 2021
FY 2021 Funding Amount: $82,750
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


TAR DNA-binding protein 43 kDa (TDP-43) is the major aggregating disease protein in amyotrophic lateral sclerosis (ALS). Over 90% of ALS cases exhibit pathological lesions containing detergent insoluble deposits of phosphorylated, truncated, and ubiquitinated TDP-43 protein. TDP-43 phosphorylated at S409/410 (pS409/410) is the most consistent, robust, and specific neuropathological feature of ALS suggesting a phosphorylated TDP-43 (pTDP) mediated cascade of neurotoxicity. Furthermore pTDP has be...

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