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Funded Project Details - FY2021




Project Number:

I01BX003625-01A1
Title: The role of ADAR2-associated RNA editing in pathogenesis of ALS
Principal Investigator:

Stella Plevan (Dracheva)

Location: Bronx, NY
Congressional District Code: 13
Research Service: Biomedical Laboratory R&D
Project Period: October 2017 - September 2021
FY 2021 Funding Amount: $356,837
Total Award Amount
(all years):
$1,406,624
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

Amyotrophic Lateral Sclerosis (ALS) is a devastating and fatal neurodegenerative disease that is characterized by progressive muscle weakness and eventual paralysis. The known risk factors for ALS are increasing age and male sex; recent data also implicate military service, thus putting an additional burden on the VA healthcare system. Approximately 90% of all ALS cases are classified as sporadic ALS (sALS) with no family history of the disease. The remaining cases are inherited in a dominant fa...



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