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Funded Project Details - FY2021

Project Number:

Title: T-cell regulation of cardiac remodeling
Principal Investigator:

Kristine DeLeon-Pennell

Location: Charleston, SC
Congressional District Code: 3
Research Service: Biomedical Laboratory R&D
Project Period: June 2017 - May 2022
FY 2021 Funding Amount: $207,916
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Veterans have 2-times higher risk of developing cardiovascular disease compared to non-veterans. For veterans who have a heart attacked (myocardial infarction; MI), 1 in 3 will not survive 1 year after the event compared to 1 in 10 in the general population. The goal of my project is to understand how the wound healing response after MI can promote the development of heart failure. My focus is the innate immune response, specifically the role of CD8+ T-cells. My central hypothesis is that CD8+ e...

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