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Funded Project Details - FY2021

Project Number:

Title: Repair of Vascular Contractility and Mitochondrial Function by NOS Recoupling
Principal Investigator:

Amy Keller

Location: Denver, CO
Congressional District Code: 1
Research Service: Biomedical Laboratory R&D
Project Period: July 2017 - June 2022
FY 2021 Funding Amount: $192,042
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Diabetes (DM) is prevalent in the Veteran community, and there is an excess risk of cardiovascular disease (CVD) in those suffering from this disease. Early signs of CVD pathology include disruptions in vascular cells, making the vasculature a prime target for novel therapeutics. Hormesis, or the ability of cells to adapt and self- regulate when exposed to stress, is disrupted in the vasculature of those with DM. A central lynchpin of homeostasis modulation is the enzyme nitric oxide synthase (N...

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