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Funded Project Details - FY2021

Project Number:

Title: BLR&D Research Career Scientist Award
Principal Investigator:

K. H. William Lau

Location: Loma Linda, CA
Congressional District Code: 31
Research Service: Biomedical Laboratory R&D
Project Period: April 2017 - March 2022
FY 2021 Funding Amount: $236,500
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


The current research focus of the nominee is two-fold: The first is to delineate a unique molecular mechanism regulating functional activity of osteoclasts that involves negative regulation of the expression of a distinctive osteoclastic protein-tyrosine phosphatase (PTP-oc), which is a potent activator of functional activity of mature osteoclasts, by microRNA-17 (miR17). This project is supported by a BLR&D Merit Review award and seeks to test 3 hypotheses: 1) resorption cytokines activates ost...

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