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Funded Project Details - FY2021




Project Number:

I01CX000920-04A2
Title: Gut reservoir of E. coli ST131
Principal Investigator:

James R. Johnson

Location: Minneapolis, MN
Congressional District Code: 5
Research Service: Clinical Science R&D
Project Period: April 2017 - March 2021
FY 2021 Funding Amount: $82,500
Total Award Amount
(all years):
$687,500
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

A new Escherichia coli strain called ST131-H30 – unknown prior to 2000 – is now the single most common cause of E. coli infections such as urinary tract infections, particularly those associated with resistance to first- line antibiotics. Veterans are especially vulnerable to ST131-H30, which causes 25-30% of all their E. coli infections, and 70-75% of those involving fluoroquinolone (e.g., ciprofloxacin) resistance. Gut colonization is an important upstream step in ST131-H30 infections, and the...



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