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Funded Project Details - FY2021

Project Number:

Title: Cardiovascular Mechanisms of Exercise Intolerance in Diabetes and the Role of Sex
Principal Investigator:

Jane E.B. Reusch

Location: Denver, CO
Congressional District Code: 1
Research Service: Clinical Science R&D
Project Period: July 2017 - June 2021
FY 2021 Funding Amount: $172,587
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Statement of Problem: Type 2 Diabetes (T2D) affects 24% of Veterans and it is associated with impaired cardiovascular exercise capacity (CVEC) which is important because of a strong relationship between CVEC and excess mortality. The goal of this proposal is to understand the contribution of preclinical cardiac, vascular dysfunction and skeletal muscle perfusion abnormalities to impaired CVEC in men and women with T2D and, further, to test the adaptive response to intervention using exercise tra...

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