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Project Number: | I01CX001560-01A1 |
| Title: | Influence of T Cell Clonality on PD-1 Blockade in Non-Small Cell Lung Cancer |
| Principal Investigator: | Nithya Ramnath |
| Location: | Ann Arbor, MI |
| Congressional District Code: | 12 |
| Research Service: | Clinical Science R&D |
| Project Period: | July 2017 - June 2021 |
| FY 2021 Funding Amount: | $222,450 |
| Total Award Amount (all years): |
$751,450 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: DESCRIPTION (provided by applicant): Lung cancer is a devastating disease that affects American War Veterans disproportionately and is the most common cause of cancer related death. Metastatic non-small cell lung cancer (NSCLC) has a 2 year survival rate of 10%. A majority of Veterans do not present actionable driver mutations in their cancers that can be treated with targeted therapies. Immunotherapy, involving checkpoint blockade (CPB) unleashes the adaptive immune response and has emerged as... |