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Funded Project Details - FY2021




Project Number:

I01CX001610-01
Title: Failure of the glutamate uptake-ascorbic acid exchange drives seizure susceptibility and severity
Principal Investigator:

James M. May

Location: Nashville, TN
Congressional District Code: 5
Research Service: Clinical Science R&D
Project Period: April 2017 - September 2021
FY 2021 Funding Amount: $82,500
Total Award Amount
(all years):
$686,990
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

Co-occurrence of seizures with Alzheimer's disease dramatically alters prognosis, and speeds cognitive de- cline. Even mild seizures that may go undetected by caregivers can increase Alzheimer's disease pathogene- sis and also independently lead to neurodegeneration and cognitive dysfunction. Subclinical (non-scorbutic) vitamin C (ascorbate) deficiency is widespread in the USA, particularly among the elderly, and veteran popula- tions where smoking and oxidative stress-related diseases such as a...



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