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Funded Project Details - FY2021

Project Number:

Title: Cognitive and Brain Changes in Preclinical Alzheimer's Disease
Principal Investigator:

Christina E. Wierenga

Location: San Diego, CA
Congressional District Code: 52
Research Service: Clinical Science R&D
Project Period: April 2017 - March 2021
FY 2021 Funding Amount: $186,172
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


The pathogenesis of Alzheimer’s disease (AD) remains unclear, though there is growing support for a synergistic relationship between vascular dysfunction and accumulation of amyloid-β and neurofibrillary tangles. Cerebrovascular disease (CVD) risk factors are prevalent in the VA population, have been linked to cognitive decline and higher risk for dementia, and may represent potential targets for remediating age-related cognitive decline. [CVD risk factors are associated with peripheral vascular...

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