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Funded Project Details - FY2021

Project Number:

Title: Cholesterol lights the fire of NASH
Principal Investigator:

George N. Ioannou

Location: Seattle, WA
Congressional District Code: 7
Research Service: Biomedical Laboratory R&D
Project Period: April 2017 - March 2022
FY 2021 Funding Amount: $76,841
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


 DESCRIPTION (provided by applicant): We reported that dietary cholesterol induces progression from simple steatosis to NASH. We subsequently discovered that cholesterol crystals were present within the lipid droplets of steatotic hepatocytes in both patients with NASH and in mouse models of NASH induced by high-fat, high-cholesterol (HFHC) diet, but not in patients or mice with simple steatosis. We described that Kupffer cells (KCs) selectively surrounded and processed steatotic hepa...

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