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Project Number: | I01RX002313-01A2 |
| Title: | Role of ryanodine receptor dysfunction after spinal cord injury |
| Principal Investigator: | Christopher Cardozo |
| Location: | Bronx, NY |
| Congressional District Code: | 13 |
| Research Service: | Rehabilitation R&D |
| Project Period: | October 2017 - September 2021 |
| FY 2021 Funding Amount: | $266,850 |
| Total Award Amount (all years): |
$1,118,425 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: Muscles paralyzed by spinal cord injury (SCI) atrophy extensively, are weaker, fatigue more quickly and generate lower specific tension (force produced per unit of cross-sectional area), such that they generate less force in response to maximal motor neuron activation. For individuals with motor-incomplete lesions, interventions that improve specific force and/or fatigue resistance would be obvious opportunities to improve function. A newly recognized cause of impaired specific force production... |