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Funded Project Details - FY2021

Project Number:

Title: Role of ryanodine receptor dysfunction after spinal cord injury
Principal Investigator:

Christopher Cardozo

Location: Bronx, NY
Congressional District Code: 13
Research Service: Rehabilitation R&D
Project Period: October 2017 - September 2021
FY 2021 Funding Amount: $266,850
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Muscles paralyzed by spinal cord injury (SCI) atrophy extensively, are weaker, fatigue more quickly and generate lower specific tension (force produced per unit of cross-sectional area), such that they generate less force in response to maximal motor neuron activation. For individuals with motor-incomplete lesions, interventions that improve specific force and/or fatigue resistance would be obvious opportunities to improve function. A newly recognized cause of impaired specific force production...

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