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Funded Project Details - FY2021

Project Number:

Title: SCI Consortium Study: Enhancing Corticospinal Tract Axonal Regeneration After Spinal Cord Injury
Principal Investigator:

Pengzhe (Paul) Lu

Location: San Diego, CA
Congressional District Code: 52
Research Service: Rehabilitation R&D
Project Period: July 2017 - June 2021
FY 2021 Funding Amount: $208,611
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Project Summary Corticospinal tract (CST) is an important supraspinal descending motor system that controls voluntary movement in humans. Good progress has been made in recent years to elicit CST axonal regeneration and re-connectivity after spinal cord injury (SCI). For example, conditional deletion of phosphatase and tensin homolog (PTEN) or pharmacological suppression of PTEN that boosts neuronal intrinsic ability to grow enhances CST sprouting and regeneration after SCI. Transplantation of n...

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