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Funded Project Details - FY2021




Project Number:

I01RX002264-01A2
Title: SCI Consortium Study: Enhancing Corticospinal Tract Axonal Regeneration After Spinal Cord Injury
Principal Investigator:

Pengzhe (Paul) Lu

Location: San Diego, CA
Congressional District Code: 52
Research Service: Rehabilitation R&D
Project Period: July 2017 - June 2021
FY 2021 Funding Amount: $208,611
Total Award Amount
(all years):
$1,027,107
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

Project Summary Corticospinal tract (CST) is an important supraspinal descending motor system that controls voluntary movement in humans. Good progress has been made in recent years to elicit CST axonal regeneration and re-connectivity after spinal cord injury (SCI). For example, conditional deletion of phosphatase and tensin homolog (PTEN) or pharmacological suppression of PTEN that boosts neuronal intrinsic ability to grow enhances CST sprouting and regeneration after SCI. Transplantation of n...



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