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Funded Project Details - FY2021

Project Number:

Title: Excess O-GlcNAc modification of proteins and myocardial fibrosis
Principal Investigator:

Francisco Villarreal

Location: San Diego, CA
Congressional District Code: 52
Research Service: Biomedical Laboratory R&D
Project Period: January 2018 - December 2021
FY 2021 Funding Amount: $249,139
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


The major hypothesis to be tested in this proposal is that, “Reducing the excess addition of β-N- acetylglucosamine (O-GlcNAc) to regulatory factors present in cardiac fibroblasts ameliorates diabetes mellitus induced myocardial fibrosis”. Given the older average age of the Veteran population, about 25% suffer from type 2 diabetes mellitus (DM2). A large number of these patients will develop DM2 induced cardiac fibrosis, which adversely impacts diastolic function and frequently leads to the deve...

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