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Funded Project Details - FY2021

Project Number:

Title: Inflammatory signaling in depression regulated by Toll-like receptors 2 and 4
Principal Investigator:

Richard S Jope

Location: Miami, FL
Congressional District Code: 24
Research Service: Biomedical Laboratory R&D
Project Period: January 2018 - December 2021
FY 2021 Funding Amount: $236,972
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


The objective of this project is to determine how inflammatory signaling by Toll-like receptor-2 (TLR2) and TLR4 regulate depression-like behaviors in mice to develop new therapeutic targets for major depression. This exciting possibility is based on our novel Preliminary Results showing that TLR4 signaling increases susceptibility to depression onset modeled in mice, whereas TLR2 signaling promotes recovery from depression. These balancing mood-regulating actions of inflammatory receptors typif...

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