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Funded Project Details - FY2021

Project Number:

Title: Combining new gene therapy with non-invasive spinal roots stimulation to improve synaptic plasticity at spino-muscular circuitry after spinal cord injury
Principal Investigator:

Victor L. Arvanian

Location: Northport, NY
Congressional District Code: 3
Research Service: Biomedical Laboratory R&D
Project Period: April 2018 - March 2022
FY 2021 Funding Amount: $354,118
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Impaired ability of voluntary walking and bladder dysfunction is an acute problem among veterans with spinal cord injuries (SCI). Results of recent studies, including our own, revealed that there are at least three major factors known to limit recovery from SCI: (1) decreased neuronal excitability, (2) presence of axonal growth/regeneration inhibitors, and (3) lack of neurotrophin support. Using animal models, we have recently demonstrated that degradation of scar-related inhibitory Chondroitin...

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