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Funded Project Details - FY2021




Project Number:

I01CX000105-05A1
Title: Targeting F-box protein 048 in acute lung injury
Principal Investigator:

Toru Nyunoya

Location: Pittsburgh, PA
Congressional District Code: 14
Research Service: Clinical Science R&D
Project Period: January 2018 - September 2022
FY 2021 Funding Amount: $65,000
Total Award Amount
(all years):
$756,122
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

Acute lung injury (ALI) is a devastating disorder among Veterans commonly occurring after sepsis or severe pneumonia. Two key manifestations of ALI are a fundamental inability to extract oxygen and inflammation, both of which may have a mitochondrial basis. Although ALI subjects have mitochondrial defects, the molecular mechanisms underlying their injury that disrupt oxygen consumption and trigger inflammation remain unclear. The mechanistic basis of this proposal resides on our discovery of a u...



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