Funded Project Details - FY2021
|Title:|| Targeting F-box protein 048 in acute lung injury|
|Congressional District Code:
||Clinical Science R&D
|| January 2018 -
|FY 2021 Funding Amount:
|Total Award Amount
View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER
Acute lung injury (ALI) is a devastating disorder among Veterans commonly occurring after sepsis or severe pneumonia. Two key manifestations of ALI are a fundamental inability to extract oxygen and inflammation, both of which may have a mitochondrial basis. Although ALI subjects have mitochondrial defects, the molecular mechanisms underlying their injury that disrupt oxygen consumption and trigger inflammation remain unclear. The mechanistic basis of this proposal resides on our discovery of a u...
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