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Funded Project Details - FY2021




Project Number:

I01BX004036-01
Title: Novel mechanisms of resistance to antiandrogen therapies
Principal Investigator:

Allen Gao

Location: Martinez, CA
Congressional District Code: 7
Research Service: Biomedical Laboratory R&D
Project Period: July 2018 - June 2022
FY 2021 Funding Amount: $156,800
Total Award Amount
(all years):
$727,795
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

Enzalutamide was approved for the treatment of metastatic castration resistant prostate cancer (CRPC). Despite these advances that provide survival gains, there is still no cure for CRPC. Resistance to enzalutamide occurs frequently and the mechanisms are incompletely understood. Hence, dissecting the specific adaptive/resistant pathways that are responsible for drug resistance in CRPC and identifying novel strategies targeting these pathways will dramatically impact the care of men with CRPC. L...



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