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Funded Project Details - FY2021

Project Number:

Title: Impairment and recovery of CD4 T cell-dependent B cell responses after sepsis
Principal Investigator:

Thomas S Griffith

Location: Minneapolis, MN
Congressional District Code: 5
Research Service: Biomedical Laboratory R&D
Project Period: January 2018 - December 2021
FY 2021 Funding Amount: $256,603
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Sepsis causes more deaths in U.S. hospitals annually than prostate cancer, breast cancer, and AIDS combined. Elderly patients are a particularly high-risk group, with an incidence rate of ~60% of all septic cases. The elderly are also extremely vulnerable to the consequences of sepsis, showing 100-fold higher mortality than younger patients. Some of these deaths occur acutely after sepsis, but ~70% of these patients survive the initial infection, and succumb to opportunistic infections during th...

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