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Funded Project Details - FY2021

Project Number:

Title: Mechanisms and Treatment of Kidney Fibrosis
Principal Investigator:

Michael Rauchman

Location: St Louis, MO
Congressional District Code: 1
Research Service: Biomedical Laboratory R&D
Project Period: January 2018 - March 2022
FY 2021 Funding Amount: $124,480
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Project Summary Chronic kidney disease (CKD) affects ~15% of the U.S. population. Although a broad range of insults initiate kidney injury, fibrosis is a hallmark of all forms of progressive CKD. In spite of advances in delineating pathways that contribute to kidney fibrosis, there are no specific treatments for this serious disorder. TGF-β signaling is a central mediator of fibrosis in multiple tissues making it an attractive therapeutic target. However, because these cytokines have a wide ra...

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